Powerpuff Girls games are based on the animated television series created by Craig McCracken. These games allow players to control Blossom, Bubbles, and Buttercup in browser-based levels that often involve action sequences, side-scrolling missions, and boss fights against villains like Mojo Jojo. The titles are designed to reflect the visual style and storyline elements of the show, and they are commonly released as Flash, HTML5, or fan-made adaptations available on gaming websites.